Testicular organoid generation by a novel in vitro three-layer gradient system
نویسندگان
چکیده
منابع مشابه
I-5: Multicellular Human Testicular Organoid: A Novel 3D In Vitro Germ Cell and Testicular Toxicity Model
Background Background: Mammalian spermatogenesis is regulated through paracrine and endocrine activity, specific cell signaling, and local control mechanisms. These highly specific signaling interactions are effectively absent upon placing testicular cells into two-dimensional primary culture. The specific changes that occur between key cell types and involved spermatogenesis signaling pathways...
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1 (Oral/Poster) MULTICELLULAR HUMAN TESTICULAR ORGANOID: A NOVEL IN VITRO GERM CELL AND TESTICULAR TOXICITY MODEL Samuel Pendergraft, MS1, Hooman Sadri-Ardekani, MD, PhD2, Tanya Reid, BS3, Anthony Atala, MD2 and Colin Bishop, PhD1 1(1) Molecular Medicine and Translational Science Graduate Program, Wake Forest University Health Sciences, Winston-Salem, NC (2) Wake Forest Institute for Regenerati...
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The extracellular matrix (ECM) exhibits tissue-specific topography and composition and plays a crucial role in initiating the biochemical and biomechanical signaling required for organizing cells into distinct tissues during development. How single cells assemble into structures featuring specific shapes in response to external cues is poorly understood. We examined the effect of substrate nano...
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This work consists in a numerically evaluation of elastic fields distribution, caused by intrinsic dislocation networks placed at a nanometric trilayers interfaces, in order to estimate their influence on the surface topology during heterostructure operation. The organization of nanostructures is ensured by the knowledge of different elastic fields caused by buried dislocation networks and calc...
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ژورنال
عنوان ژورنال: Biomaterials
سال: 2017
ISSN: 0142-9612
DOI: 10.1016/j.biomaterials.2017.03.025